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Tracing colophonium in consumer products.

Ann-Therese Karlberg¹, Mhd-Hussam Albadr², Ulrika Nilsson²

¹Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

Contact Dermatitis

|July 22, 2021

Summary

Measuring colophonium (rosin) in products requires analyzing all major resin acids, not just abietic acid (AbA). The ratio of 7-oxodehydroabietic acid (7-O-DeA) to AbA indicates autoxidation and sensitization risk.

Keywords:

chemical analysis colophonium consumer products regulation resin acids rosin [CAS no. 8050-09-7]

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Area of Science:

Analytical Chemistry
Dermatology
Consumer Product Safety

Background:

Colophonium (rosin) is a common cause of allergic contact dermatitis.
Abietic acid (AbA) autoxidation is the primary mechanism for colophonium-induced allergies.
Accurate quantification of colophonium in consumer products is essential for regulatory compliance (EUH208 labeling).

Purpose of the Study:

To compare methods for estimating colophonium content in consumer goods.
To evaluate estimation based on abietic acid (AbA) versus the total sum of major resin acids.
To assess the 7-oxodehydroabietic acid (7-O-DeA)/AbA ratio as an indicator of colophonium autoxidation.

Main Methods:

Extraction of resin acids from consumer products.
Derivatization of extracted resin acids.
Analysis using gas chromatography/mass spectrometry (GC/MS).

Main Results:

Resin acids were detected in 9 out of 15 tested products; none exceeded the 0.1% colophonium threshold.
Estimating colophonium solely from AbA led to underestimation in 4 products.
The sum of all resin acids provided a more accurate colophonium quantification than AbA alone.

Conclusions:

Quantifying colophonium should involve summing all detectable major resin acids, including 7-O-DeA.
The 7-O-DeA/AbA ratio serves as a marker for autoxidation and potential sensitization risk.
The developed GC/MS method is practical for screening studies and regulatory applications.