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Fast imaging of CSF flow/motion patterns using steady-state free precession (SSFP)
F A Jolesz1, S Patz, R C Hawkes
1Department of Radiology, Harvard Medical School, Boston, Massachusetts.
Investigative Radiology
|October 1, 1987
Summary
This study shows a fast brain MRI technique can detect abnormal cerebrospinal fluid (CSF) flow patterns in conditions like hydrocephalus, aiding diagnosis.
Area of Science:
- Neuroimaging
- Medical Physics
- Neurology
Background:
- Cerebrospinal fluid (CSF) dynamics are crucial for brain health.
- Abnormal CSF flow patterns are associated with various neurological conditions, including hydrocephalus.
- Accurate assessment of CSF flow is essential for diagnosis and management.
Purpose of the Study:
- To evaluate a rapid Fourier steady-state free precession (SSFP) magnetic resonance imaging (MRI) technique for assessing CSF flow patterns.
- To investigate the potential diagnostic utility of this technique in identifying deviations from normal CSF dynamics.
Main Methods:
- A rapid Fourier SSFP imaging technique sensitive to slow, in-plane flow (approx. 1 mm/sec) was employed.
- 135 brain MRI examinations were acquired.
- CSF flow/motion patterns were mapped using two images with orthogonal in-plane flow sensitivity directions.
Main Results:
- Significant deviations from normal CSF flow patterns were observed in cases of ventricular enlargement due to obstruction (absent flow).
- Complex and intensive flow patterns within the lateral ventricles were identified in normal pressure hydrocephalus.
- The technique demonstrated sensitivity to subtle flow changes.
Conclusions:
- The rapid Fourier SSFP MRI technique shows promise for the non-invasive assessment of CSF dynamics.
- This imaging method has potential diagnostic value for conditions characterized by altered CSF flow, such as obstructive hydrocephalus and normal pressure hydrocephalus.