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Opiate involvement in contrast media-induced blood pressure changes
P P Harnish1, M Mukherji, F K Northington
1Department of Radiology, University of Rochester Medical Center, New York 14642.
Investigative Radiology
|November 1, 1987
Summary
Intravenous contrast media can alter blood pressure (BP). Research suggests endogenous opioids, blocked by naloxone, may mediate BP changes from contrast media (CM).
Area of Science:
- Pharmacology
- Physiology
- Radiology
Background:
- Intravenous contrast media (CM) administration frequently impacts blood pressure (BP).
- While osmolality influences BP changes, other mechanisms are implicated due to variable responses.
- Endogenous opioid system involvement in CM-induced BP alterations is suspected.
Purpose of the Study:
- To investigate the role of endogenous opioids in mediating blood pressure changes following intravenous contrast media administration.
- To determine if naloxone, an opiate antagonist, can prevent contrast media-induced blood pressure alterations.
Main Methods:
- Male Wistar rats were administered sodium/meglumine diatrizoate or iohexol intravenously.
- Blood pressure was continuously monitored.
- Groups were pretreated with naloxone (opiate antagonist) or saline before diatrizoate injection.
Main Results:
- Diatrizoate significantly increased BP compared to saline controls.
- Iohexol did not significantly alter BP.
- Naloxone pretreatment prevented the diatrizoate-induced BP increase, unlike saline pretreatment.
Conclusions:
- The release of endogenous opioids may contribute to blood pressure changes induced by intravenous contrast media.
- Pharmacological intervention with naloxone can potentially prevent significant contrast media-induced blood pressure alterations.