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Updated: Oct 27, 2025

Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Published on: October 10, 2013

Saliva as new analytical object for D-dimer level determination.

O O Yanushevish¹, H E Dukhovskaya¹, T P Vavilova¹

¹A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation.

Klinicheskaia Laboratornaia Diagnostika

|July 22, 2021

Summary

Saliva D-dimer levels rise with age in healthy individuals and those with comorbidities. Erosive gastritis patients showed the highest D-dimer concentrations in saliva, indicating a potential biomarker connection.

Keywords:

D-dimer comorbidities saliva

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Area of Science:

Biochemistry
Clinical Diagnostics
Gerontology

Background:

D-dimer is a fibrin degradation product.
Elevated D-dimer is associated with thrombotic events.
Salivary diagnostics are an emerging field.

Purpose of the Study:

To investigate D-dimer levels in mixed saliva.
To compare D-dimer in healthy individuals and patients with comorbidities.
To assess the influence of age and specific pathologies on salivary D-dimer.

Main Methods:

Saliva samples collected from diverse cohorts.
Quantitative analysis of D-dimer concentration.
Statistical analysis to correlate D-dimer with age and health status.

Main Results:

Salivary D-dimer levels increase with age across all groups.
Patients with comorbidities exhibited altered D-dimer levels.
The highest D-dimer concentrations were observed in individuals with erosive gastritis.

Conclusions:

Age is a significant factor influencing salivary D-dimer.
Salivary D-dimer may serve as a biomarker for certain conditions.
Erosive gastritis is associated with markedly elevated salivary D-dimer.