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Updated: Sep 2, 2025
Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
[Proteomic saliva assay in patients with COVID-19]
O O Yanuchevish1, I V Mayev1, E A Karton1
1Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia.
The Aim Of The Study:
Was to perform proteomic saliva assay in order to reveal mechanisms of the oral pathology caused by COVID-19.
Materials And Methods:
Proteomic analysis was performed to compare saliva proteins profile in healthy individuals (10 samples) and patients with COVID-19 (30 samples).
Results:
The obtained results of the saliva samples study in patients with COVID-19 indicate activation in the oral tissues the pathways of the cell renewal, apoptosis, DNA exchange processes and chromatin remodelling; there are also marked signs of immune response reactivation and immunostimulation.
Conclusion:
Of all the proteins presented, the saliva of patients with COVID-19 33 proteins have an intersection with GO-annotated proteins of inflammation and epithelial cornification.
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