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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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Cyclodextrin-linked PVP/PEG supramolecular hydrogels.

Seyma Nur Kirmic Cosgun1, Deniz Ceylan Tuncaboylu1

  • 1Bezmialem Vakif University, Faculty of Pharmacy, 34093 Istanbul, Turkey.

Carbohydrate Polymers
|July 23, 2021
PubMed
Summary
This summary is machine-generated.

We created novel supramolecular hydrogels using cyclodextrin (CD) crosslinking poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP) chains. These stable, water-insoluble gels exhibit self-healing properties, tunable via component ratios and PEG molecular weight.

Keywords:
CyclodextrinPoly(N-vinylpyrrolidone)Poly(ethylene glycol)Self-healingSupramolecular

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Area of Science:

  • Polymer Science
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Supramolecular hydrogels offer tunable properties for various applications.
  • Cyclodextrin (CD)-host guest interactions are effective for creating reversible networks.
  • Poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP) are biocompatible polymers suitable for hydrogel formation.

Purpose of the Study:

  • To develop novel supramolecular hydrogels using cyclodextrin (CD) as a crosslinking agent.
  • To investigate the influence of PEG molecular weight and feed ratios on hydrogel properties.
  • To explore the potential for self-healing properties through synergistic crosslinking.

Main Methods:

  • Supramolecular hydrogels were synthesized by crosslinking PEG and PVP chains with cyclodextrin (CD) molecules.
  • The effect of varying PEG molecular weights (≥10 kDa) and component feed ratios on gel properties was analyzed.
  • Synergistic physical and chemical crosslinking was achieved by incorporating poly(ethylene glycol) dimethacrylate (PEGDMA).

Main Results:

  • Water-insoluble supramolecular hydrogels were successfully formed through α-CD-PEG inclusion complexes and hydrogen bonding.
  • Increasing PEG concentration decreased elastic/viscous modulus and tensile capacity.
  • Stable, swelling-resistant gels were obtained with PEG molecular weight ≥10 kDa.
  • The addition of PEGDMA resulted in stable networks with self-healing capabilities.

Conclusions:

  • Supramolecular hydrogels with tunable properties can be fabricated using CD-based crosslinking.
  • PEG molecular weight and feed ratios are critical parameters for controlling hydrogel network characteristics.
  • The developed hydrogels demonstrate potential for applications requiring stable, self-healing materials.