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Advances in Biological Functions and Clinical Studies of FGF21

Wei Lin1, Tianlei Zhang1, Yiyang Zhou2

  • 1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|July 23, 2021
PubMed

Insights

Fibroblast growth factor 21 (FGF21) impacts metabolism and injury protection. Understanding its pathways aids in treating metabolic diseases and injuries.

Area of Science:

  • Endocrinology and Metabolism
  • Molecular Biology
  • Cellular Signaling

Background:

  • Fibroblast growth factor 21 (FGF21) is a key regulator of metabolic processes in mammals.
  • FGF21 demonstrates significant protective effects following various types of injury.
  • Elucidating FGF21's complex regulatory mechanisms is crucial for advancing medical treatments.

Purpose of the Study:

  • To review the metabolic modulation functions of FGF21.
  • To summarize the protective effects of FGF21, particularly after injury.
  • To explore the molecular mechanisms and clinical developments related to FGF21.

Main Methods:

  • Literature review of existing studies on FGF21.
  • Analysis of research on FGF21's role in metabolic regulation.
  • Synthesis of data on FGF21's protective effects and signaling pathways.

Main Results:

  • FGF21 plays a vital role in modulating glucose and lipid metabolism.
  • FGF21 exhibits potent protective effects against diverse injuries, including metabolic stress.
  • The signaling pathways of FGF21 involve complex interactions with cellular receptors and downstream effectors.

Conclusions:

  • FGF21 is a critical factor in metabolic homeostasis and injury response.
  • Further research into FGF21 pathways can lead to novel therapeutic strategies.
  • Understanding FGF21's mechanisms is essential for developing treatments for metabolic and injury-related diseases.
Keywords:
clinical applicationfibroblast growth factor 21metabolic modulationmolecular mechanismsprotective effect

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