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Updated: Oct 27, 2025
06:09
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
7.1K
A breathless teenager
Cara N Cochrane1, Neil Collin2, Simon C Langton Hewer3
1Dept of Paediatrics, Royal United Hospital, Bath, UK.
Breathe (Sheffield, England)
|July 23, 2021
Summary
Intranodal lymphangiography helps identify lymphatic leaks in children with persistent chylothoraces. This minimally invasive procedure may enable targeted embolization for treatment and resolution of the condition.
Area of Science:
- Pediatric Interventional Radiology
- Thoracic Surgery
- Lymphatic Imaging
Background:
- Persistent chylothorax in children, especially of unknown origin, presents a significant clinical challenge.
- Identifying the specific lymphatic leak source is crucial for effective treatment.
Purpose of the Study:
- To evaluate the utility of intranodal lymphangiography in diagnosing the origin of persistent chylothoraces in pediatric patients.
- To assess the potential for subsequent embolization therapy guided by lymphangiography.
Main Methods:
- Intranodal lymphangiography was performed in pediatric patients with idiopathic persistent chylothoraces.
- Diagnostic imaging identified the site of lymphatic leakage.
- Image-guided embolization using glue and coils was employed for treatment.
Main Results:
- Intranodal lymphangiography successfully localized the lymphatic leak in affected children.
- Embolization procedures resulted in resolution or significant improvement of chylothoraces.
Conclusions:
- Intranodal lymphangiography is an effective tool for diagnosing the source of pediatric chylothoraces.
- This technique facilitates targeted embolization, offering a potential therapeutic solution for this challenging condition.
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