Related Experiment Video
Updated: Oct 27, 2025
The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
CAM-DR: Mechanisms, Roles and Clinical Application in Tumors
Yuejiao Huang1,2, Yuchan Wang3, Jie Tang3
1Medical School, Nantong University, Nantong, China.
Abstract:
Despite the continuous improvement of various therapeutic techniques, the overall prognosis of tumors has been significantly improved, but malignant tumors in the middle and advanced stages still cannot be completely cured. It is now evident that cell adhesion-mediated resistance (CAM-DR) limits the success of cancer therapies and is a great obstacle to overcome in the clinic. The interactions between tumor cells and extracellular matrix (ECM) molecules or adjacent cells may play a significant role in initiating the intracellular signaling pathways that are associated with cell proliferation, survival upon binding to their ligands. Recent studies illustrate that these adhesion-related factors may contribute to the survival of cancer cells after chemotherapeutic therapy, advantageous to resistant cells to proliferate and develop multiple mechanisms of drug resistance. In this review, we focus on the molecular basis of these interactions and the main signal transduction pathways that are involved in the enhancement of the cancer cells' survival. Furthermore, therapies targeting interactions between cancer cells and their environment to enhance drug response or prevent the emergence of drug resistance will also be discussed.
Insights
Cell adhesion-mediated resistance (CAM-DR) hinders cancer therapy success by promoting tumor cell survival. Targeting cell-environment interactions could overcome drug resistance and improve treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Malignant tumors, especially in advanced stages, remain challenging to cure despite therapeutic advancements.
- Cell adhesion-mediated resistance (CAM-DR) is a significant barrier to effective cancer treatment.
- Tumor cell interactions with the extracellular matrix (ECM) and neighboring cells activate survival pathways.
Purpose of the Study:
- To review the molecular mechanisms underlying CAM-DR in cancer.
- To explore signal transduction pathways that enhance cancer cell survival via adhesion.
- To discuss therapeutic strategies targeting cell-environment interactions to improve drug response and prevent resistance.
Main Methods:
- Literature review focusing on molecular basis of cell adhesion in cancer.
- Analysis of signaling pathways involved in CAM-DR.
- Discussion of emerging therapeutic approaches targeting tumor microenvironment interactions.
Main Results:
- Cell adhesion interactions promote cancer cell survival and proliferation.
- CAM-DR contributes to resistance against chemotherapeutic agents.
- Adhesion-related signaling pathways are crucial for cancer cell persistence.
Conclusions:
- Understanding CAM-DR molecular basis is vital for improving cancer therapy.
- Targeting cell-ECM and cell-cell interactions offers potential to overcome drug resistance.
- Novel therapies focused on the tumor microenvironment may enhance treatment efficacy.
More Related Videos
12:23Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
Published on: August 14, 2012
07:03Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
Published on: February 3, 2021
