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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Long non-coding RNAs: Emerging roles in periodontitis
Jingchen Xu1, Yuanyuan Yin1, Yao Lin1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Journal of Periodontal Research
|July 23, 2021
Summary
Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in periodontitis, a common inflammatory gum disease. Research highlights their potential as diagnostic markers and therapeutic targets for this public health burden.
Area of Science:
- Molecular Biology
- Genetics
- Periodontology
Background:
- Periodontitis affects 20-50% of the global population, causing tooth loss and exacerbating systemic diseases.
- Understanding periodontitis's molecular mechanisms is crucial for developing targeted therapies.
- Long non-coding RNAs (lncRNAs) are key regulators in biological and pathological processes.
Purpose of the Study:
- To review the biogenesis, characteristics, and functions of lncRNAs.
- To summarize the emerging roles of lncRNAs in periodontal cell regulation (proliferation, apoptosis, inflammation, osteogenesis).
- To elucidate the role of lncRNAs in periodontitis physiopathology, including interactions with microRNAs.
Main Methods:
- Literature review of recent research on lncRNAs in periodontitis.
- Analysis of lncRNA involvement in cellular processes relevant to periodontal health.
- Examination of lncRNA-microRNA interactions in periodontitis pathology.
Main Results:
- Numerous dysregulated lncRNAs are implicated in periodontitis.
- lncRNAs regulate critical cellular functions in periodontal tissues.
- lncRNA-microRNA interactions are key mechanisms in periodontitis pathogenesis.
Conclusions:
- lncRNAs play significant roles in the physiopathology of periodontitis.
- lncRNAs show potential as diagnostic and prognostic biomarkers for periodontitis.
- lncRNAs represent promising therapeutic targets for periodontitis treatment.
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