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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Translational Regulation01:29

Translational Regulation

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Related Experiment Video

Updated: Oct 27, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Long non-coding RNAs: Emerging roles in periodontitis.

Jingchen Xu1, Yuanyuan Yin1, Yao Lin1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Periodontal Research
|July 23, 2021
PubMed
Summary

Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in periodontitis, a common inflammatory gum disease. Research highlights their potential as diagnostic markers and therapeutic targets for this public health burden.

Keywords:
biomarkerlong non-coding RNAspathophysiologyperiodontitistherapeutic target

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Area of Science:

  • Molecular Biology
  • Genetics
  • Periodontology

Background:

  • Periodontitis affects 20-50% of the global population, causing tooth loss and exacerbating systemic diseases.
  • Understanding periodontitis's molecular mechanisms is crucial for developing targeted therapies.
  • Long non-coding RNAs (lncRNAs) are key regulators in biological and pathological processes.

Purpose of the Study:

  • To review the biogenesis, characteristics, and functions of lncRNAs.
  • To summarize the emerging roles of lncRNAs in periodontal cell regulation (proliferation, apoptosis, inflammation, osteogenesis).
  • To elucidate the role of lncRNAs in periodontitis physiopathology, including interactions with microRNAs.

Main Methods:

  • Literature review of recent research on lncRNAs in periodontitis.
  • Analysis of lncRNA involvement in cellular processes relevant to periodontal health.
  • Examination of lncRNA-microRNA interactions in periodontitis pathology.

Main Results:

  • Numerous dysregulated lncRNAs are implicated in periodontitis.
  • lncRNAs regulate critical cellular functions in periodontal tissues.
  • lncRNA-microRNA interactions are key mechanisms in periodontitis pathogenesis.

Conclusions:

  • lncRNAs play significant roles in the physiopathology of periodontitis.
  • lncRNAs show potential as diagnostic and prognostic biomarkers for periodontitis.
  • lncRNAs represent promising therapeutic targets for periodontitis treatment.