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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

444
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
444
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

477
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
477
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

576
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
576
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

280
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
280
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

465
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
465
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

246
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
246

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Related Experiment Video

Updated: Oct 27, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

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Systemic Inflammation in Preclinical Ulcerative Colitis.

Daniel Bergemalm1, Erik Andersson1, Johan Hultdin2

  • 1Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Gastroenterology
|July 23, 2021
PubMed
Summary
This summary is machine-generated.

Preclinical ulcerative colitis shows elevated inflammatory proteins years before diagnosis. These markers accurately predict disease onset and may indicate early exposure to genetic and environmental risk factors.

Keywords:
CXCL9Inflammatory Bowel DiseaseMMP10Preclinical DiseaseProximity Extension Assay

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Last Updated: Oct 27, 2025

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Area of Science:

  • Gastroenterology
  • Immunology
  • Biomarker Discovery

Background:

  • Preclinical ulcerative colitis (UC) lacks clear definition, hindering early intervention.
  • Systemic inflammation is implicated in UC pathogenesis but poorly characterized pre-diagnosis.

Purpose of the Study:

  • To identify and characterize preclinical systemic inflammation in individuals who later develop ulcerative colitis.
  • To determine the predictive value of identified protein markers for future UC diagnosis.

Main Methods:

  • Analyzed plasma samples from individuals who developed UC and matched controls using a proximity extension assay to measure 92 inflammation-related proteins.
  • Validated findings in an inception cohort and explored genetic/environmental influences in healthy twin siblings of UC patients.

Main Results:

  • Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11, MCP-1) were significantly up-regulated in preclinical UC.
  • A multivariable model using these proteins predicted UC diagnosis with high accuracy (AUC = 0.92).
  • Some markers (MMP10, CXCL9, CXCL11, MCP-1) were elevated in healthy twins, suggesting early exposure to risk factors.

Conclusions:

  • Specific inflammatory proteins are elevated years before UC diagnosis.
  • These proteins serve as potent predictors of future UC development.
  • Elevated markers in healthy twins suggest early influence of genetic and environmental risk factors.