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Cyanide poisoning from propionitrile exposure
C Bismuth1, F J Baud, H Djeghout
1Hôpital Fernand Widal, Université de Paris, France.
The Journal of Emergency Medicine
|May 1, 1987
Summary
Propionitrile exposure can cause severe cyanide poisoning. Prompt treatment with hydroxycobalamin and sodium thiosulfate rapidly reversed symptoms and normalized blood cyanide levels in a worker.
Area of Science:
- Toxicology
- Occupational Health
Background:
- Propionitrile is an industrial chemical with potential toxicity.
- Cyanide poisoning is a life-threatening condition requiring rapid diagnosis and treatment.
Observation:
- A 55-year-old worker experienced loss of consciousness and metabolic acidosis after propionitrile exposure via inhalation and dermal routes.
- Clinical presentation was consistent with acute cyanide poisoning.
Findings:
- Treatment with hydroxycobalamin and sodium thiosulfate led to complete symptom resolution within one hour.
- Monitoring of blood levels showed a rapid decrease in cyanide and a corresponding increase in thiocyanate.
Implications:
- This case highlights the significant risk of cyanide poisoning from propionitrile exposure in occupational settings.
- Hydroxycobalamin and sodium thiosulfate are effective antidotes for propionitrile-induced cyanide poisoning, facilitating swift clinical recovery.