Excessive daytime sleepiness in idiopathic blepharospasm
Jing Yang1, Lingyu Zhang1, Yanbing Hou1
1Department of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Parkinsonism & Related Disorders
|July 23, 2021
Summary
Excessive daytime sleepiness (EDS) is more common in idiopathic blepharospasm patients, impacting their quality of life. Managing EDS is crucial for addressing associated mood and cognitive issues.
Area of Science:
- Neurology
- Sleep Medicine
- Ophthalmology
Background:
- Idiopathic blepharospasm (IB) is a rare neurological disorder characterized by involuntary eyelid closure.
- Excessive daytime sleepiness (EDS) is a common complaint, but its prevalence and impact in IB patients are not well-understood.
Purpose of the Study:
- To determine the frequency of EDS in patients with idiopathic blepharospasm.
- To investigate the association between EDS and quality of life, as well as clinical factors in IB.
- To identify predictors of EDS in the IB population.
Main Methods:
- A cross-sectional study involving 425 IB patients and 424 healthy controls.
- Assessment of EDS using the Epworth Sleepiness Scale (ESS).
- Evaluation of motor symptoms, sleep quality, depression (HDRS), anxiety (HARS), cognition (MoCA), and quality of life (SF-36) in IB patients.
Main Results:
- EDS was significantly more frequent in IB patients (22.1%) compared to controls (12.3%).
- IB patients with EDS exhibited higher motor scores, depression, and anxiety, alongside lower cognitive scores and quality of life.
- Male sex, younger age of onset, higher motor scores, higher HDRS, and lower MoCA scores were associated with EDS in IB.
Conclusions:
- EDS is prevalent in idiopathic blepharospasm and negatively impacts quality of life.
- Management of EDS is essential for improving the overall well-being of IB patients.
- The findings suggest potential abnormal sleep-wake patterns in IB, highlighting the disease's clinical heterogeneity.
More Related Videos
Related Concept Videos
01:07Narcolepsy
252
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
252
01:24Sleep-Wake Cycles
1.9K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.9K
01:15REM Sleep Behavior Disorder
559
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
559
01:19Management of Insomnia
354
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
354
01:17Accessory Structures of the Eye
2.3K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
2.3K
01:17Sleepwalking and Sleep Talking
402
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
402