Related Experiment Video

Updated: Oct 27, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.5K

Bicuspid Aortic Valve Is Associated with Less Coronary Calcium and Coronary Artery Disease Burden

Gudrun Feuchtner1, Sven Bleckwenn1, Leon Stoessl2

  • 1Department Radiology, Innsbruck Medical University, 6020 Innsbruck, Austria.

Journal of Clinical Medicine
|July 24, 2021
PubMed

Insights

Patients with bicuspid aortic valve (BAV) stenosis have significantly less coronary artery calcium and less severe coronary artery disease compared to those with tricuspid aortic valve (TAV) stenosis. Coronary computed tomography angiography effectively rules out obstructive coronary artery disease in most BAV patients.

Area of Science:

  • Cardiovascular Imaging
  • Cardiac Surgery
  • Genetics and Cardiovascular Disease

Background:

  • Bicuspid aortic valve (BAV) is linked to genetic factors and aortopathy, potentially influencing coronary arteries.
  • Understanding coronary artery disease (CAD) burden in BAV stenosis is crucial for patient management and procedural planning.

Purpose of the Study:

  • To compare coronary artery calcium score (CACS) and CAD burden between patients with BAV stenosis and tricuspid aortic valve (TAV) stenosis.
  • To evaluate the utility of coronary computed tomography angiography (CTA) in assessing CAD in BAV stenosis.

Main Methods:

  • Retrospective case-control study matching 47 BAV stenosis patients with 47 TAV stenosis patients.
  • Patients underwent coronary computed tomography angiography (CTA) for assessment of coronary artery calcium score (CACS) and coronary artery disease (CAD) severity.
  • Matching criteria included age, gender, smoking status, hypertension, dyslipidemia, diabetes, BMI, and chronic kidney disease.

Main Results:

  • Significantly lower CACS (237.4 vs. 1013.3 AU; p < 0.001) and less severe stenosis (CAD-RAD™; p < 0.001) in BAV stenosis patients compared to TAV stenosis.
  • More BAV patients had a CACS of zero (27.7% vs. 0%; p < 0.001).
  • Non-obstructive CAD was more prevalent in BAV stenosis (68.1%) than in TAV stenosis (25.5%; p < 0.001), while obstructive CAD was more frequent in TAV stenosis (68.1%; p < 0.001).

Conclusions:

  • Patients with BAV stenosis exhibit substantially reduced coronary calcification and less severe coronary stenosis.
  • CTA is effective in excluding obstructive CAD in the majority of BAV stenosis patients.
  • Findings have implications for transcatheter aortic valve replacement (TAVR) planning in BAV patients.

Keywords:
bicuspid aortic valvecomputed tomographycoronary artery diseasecoronary calcium

More Related Videos

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.5K
Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.3K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
172
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
542
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
328
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
111
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
96
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
424