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Related Experiment Video

Updated: Oct 27, 2025

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Fabrication of Cardiac Constructs Using Bio-3D Printer.

Kenichi Arai1, Daiki Murata1, Shoko Takao1

  • 1Center for Regenerative Medicine Research, Faculty of Medicine, Saga University, Saga, Japan.

Methods in Molecular Biology (Clifton, N.J.)
|July 24, 2021
PubMed
Summary

Researchers developed a bio-3D printer to create cardiac tissue from human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). These engineered tissues show potential for regenerative medicine and drug discovery applications.

Keywords:
Bio-3D printerBiofabricationCardiac constructHuman induced pluripotent stem cell-derived cardiomyocytesScaffold-free

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Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • Three-dimensional (3D) cardiac tissue fabrication is crucial for regenerative medicine and drug discovery.
  • Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer a promising cell source for cardiac tissue engineering.

Purpose of the Study:

  • To report the development of a novel bio-3D printer for fabricating tubular cardiac constructs.
  • To establish protocols for evaluating the functional properties of these engineered cardiac tissues.

Main Methods:

  • Fabrication of tubular cardiac constructs using a bio-3D printer with human iPSC-CMs.
  • Evaluation of contractile force and electrophysiological response of the cardiac constructs.

Main Results:

  • Successful fabrication of tubular cardiac constructs solely from human iPSC-CMs.
  • Demonstrated contractile function and response to electrical stimulation in the engineered tissues.
  • Validated protocols for assessing tissue function.

Conclusions:

  • The developed bio-3D printing technology enables the creation of functional cardiac constructs from iPSC-CMs.
  • These constructs are suitable for transplantation and drug response testing.
  • Engineered cardiac tissues hold potential as alternatives to animal models and for future heart transplantation therapies.