Long-term prognosis of polypoidal choroidal vasculopathy with a 5-year remission after an initial combination therapy

To investigate the visual prognosis of patients with polypoidal choroidal vasculopathy (PCV) with a 5-year remission after an initial combination therapy involving photodynamic therapy (PDT) and intravitreal ranibizumab (IVR) or aflibercept injection (IVA).

Medical records of 69 consecutive patients with PCV treated with PDT with IVR/IVA were retrospectively reviewed, and 17 eyes were identified with a 5-year remission after the initial combination therapy. The eyes that did not require additional treatment during the 1^st-5^th year were assigned to the remission group and the eyes requiring additional treatment during the 1^st-5^th year were assigned to the recurrence group.

During the 7-year follow-up, the mean logarithm of the minimal angle resolution best-corrected visual acuity (logMAR BCVA) significantly improved from 0.39±0.27 to 0.17±0.38 (p=2.9 × 10^-4) in the remission group, whereas the mean logMAR BCVA was maintained throughout the follow-up period (0.58±0.27 to 0.60±0.48) in the recurrence group. In the remission group, only two (11.8%) of the 17 eyes experienced recurrence during the 5^th-7^th year. Comparison of baseline characteristics between the two groups revealed that a higher proportion of female (p=0.012), better baseline BCVA (p=3.1 × 10^-3), and lower risk allele frequency in ARMS2 A69S (p=0.029) were observed in the remission group.

The combination therapy showed a favourable outcome for PCV over a 7-year follow-up, especially in the eyes without recurrence during the 1^st-5^th year. Physicians should be careful of recurrent exudation in the eyes without recurrence during the 1^st-5^th years, although the recurrence rate was low.