Immune Deficiency Does Not Increase Inflatable Penile Prosthesis Reoperation Rates.

Area of Science:

• Urology
• Andrology
• Surgical Outcomes

Background:

• Post-operative infection is a concern in immunocompromised patients.
• The impact of immune status on inflatable penile prosthesis (IPP) reoperation rates is not well-established.

Purpose of the Study:

• To investigate if immunocompromised men have higher rates of IPP reoperation compared to immunocompetent men.
• To analyze reoperation causes including infection, erosion, device malfunction, and dissatisfaction.

Main Methods:

• Retrospective analysis of the New York Statewide Planning and Research Cooperative System database (2000-2016).
• Propensity-score matching of 235 immunocompromised patients with 705 immunocompetent controls.
• Kaplan-Meier analysis and Cox proportional hazards models to compare reoperation rates at 30 days, 90 days, 1 year, and 3 years.

Main Results:

• No significant difference in overall reoperation rates between immunocompromised and immunocompetent groups at any time point.
• Reoperation due to infection, removal, or revision/replacement showed no significant difference between groups.
• Hazard ratios for reoperation, removal, and revision/replacement were not statistically significant between the two groups.

Conclusions:

• Immune status does not appear to significantly increase the risk of inflatable penile prosthesis reoperation in appropriately selected candidates.
• Reoperation rates, including those due to infection, are comparable between immunocompromised and immunocompetent men.
• IPP outcomes are not substantially affected by immune deficiency in this patient cohort.