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Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials

Melodi Omraninava1, Bahman Razi2, Saeed Aslani3

  • 1Department of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran.

European Journal of Pharmacology
|July 25, 2021
PubMed

Insights

Resveratrol effectively reduces levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in inflammatory conditions, particularly at higher doses. However, it does not significantly impact interleukin-1 (IL-1) or interleukin-8 (IL-8) levels.

Area of Science:

  • Biochemistry
  • Immunology
  • Pharmacology

Background:

  • Inflammatory cytokines like IL-1, IL-6, IL-8, and TNF-α play critical roles in various inflammatory diseases.
  • Resveratrol, a natural polyphenol, has demonstrated anti-inflammatory properties in preclinical studies.
  • Understanding the precise impact of resveratrol on specific inflammatory markers is crucial for therapeutic applications.

Purpose of the Study:

  • To conduct a meta-analysis of randomized clinical trials evaluating resveratrol's efficacy in reducing serum levels of IL-1, IL-6, IL-8, and TNF-α.
  • To synthesize existing evidence on resveratrol's anti-inflammatory effects across a spectrum of inflammatory conditions.
  • To determine the dose-dependent effects of resveratrol on inflammatory cytokine levels.

Main Methods:

  • A comprehensive literature search was performed across major scientific databases (Scopus, Web of Science, Medline, Cochrane Library) up to September 2020.
  • Meta-analysis of 33 selected randomized clinical trials was conducted using weighted mean differences (WMD) and 95% confidence intervals (CI).
  • Quantitative analysis focused on changes in IL-1, IL-6, IL-8, and TNF-α levels between resveratrol and control groups.

Main Results:

  • Resveratrol consumption significantly reduced serum TNF-α levels (WMD = -0.66 pg/ml, P = 0.001).
  • A significant reduction in IL-6 was observed only with doses of ≥500 mg/day (WMD = -1.89 pg/ml, P = 0.04), with high heterogeneity.
  • No significant alterations were found in IL-1 (WMD = -0.14 pg/ml, P = 0.10) or IL-8 (WMD = 0.18 pg/ml, P = 0.73) levels.

Conclusions:

  • Resveratrol demonstrates a significant capacity to lower TNF-α levels in patients with inflammatory diseases.
  • Higher doses of resveratrol (≥500 mg/day) are associated with a significant reduction in IL-6 levels.
  • Resveratrol does not appear to significantly affect IL-1 or IL-8 levels, suggesting a targeted anti-inflammatory action on specific cytokines.
Keywords:
IL-1IL-6IL-8InflammationMeta-analysisRandomized clinical trialResveratrolTNF-α

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