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Antinociceptive C19-diterpenoid alkaloids from the root of Aconitum episcopale
Jiang Hu1, Jia-Xun Li2, Qiang Li1
1College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
Abstract:
A chemical investigation on the roots of Aconitum episcopale afforded three undescribed aconitine-type C19-diterpenoid alkaloids, episcopalines A-C (1-3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for their antinociceptive properties. As a result, episcopaline B (2) showed potent antinociceptive effect and its ID50 value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
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