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Role of Hippocampus in Memory

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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Oct 26, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

Published on: November 10, 2015

Surface-based hippocampal subfield segmentation.

Jordan DeKraker¹, Stefan Köhler², Ali R Khan³

¹Brain and Mind Institute, University of Western Ontario, London, ON, Canada; Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Trends in Neurosciences

|July 26, 2021

Summary

This summary is machine-generated.

Hippocampal folding patterns vary significantly, complicating brain analysis. Surface-based methods, applied to magnetic resonance imaging (MRI) data, offer a novel solution for aligning and segmenting the hippocampus, improving morphological characterization.

Keywords:

MRI computational anatomy gyrification histology registration topology

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Last Updated: Oct 26, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging

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Published on: November 10, 2015

Horizontal Hippocampal Slices of the Mouse Brain

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Published on: September 22, 2020

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

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Published on: April 3, 2021

Area of Science:

Neuroscience
Neuroimaging
Computational Anatomy

Background:

The hippocampus, despite being termed 'subcortical,' is an archicortical structure connected to the neocortex.
Significant interindividual variability in human hippocampal folding poses challenges for alignment and subfield segmentation.
Conventional manual or registration-based segmentation methods for hippocampal subfields have inherent limitations.

Purpose of the Study:

To discuss surface-based methods for modeling hippocampal folding.
To enable interindividual alignment in an unfolded 2D space, analogous to neocortical approaches.
To improve morphological characterization and subfield segmentation of the hippocampus.

Main Methods:

Application of surface-based modeling techniques to explicitly represent hippocampal folding.
Utilizing magnetic resonance imaging (MRI) data for analysis.
Developing methods for interindividual alignment in a flat-mapped 2D space.

Main Results:

Surface-based methods allow for detailed morphological characterization of the hippocampus.
These methods constrain the complexity of hippocampal subfield segmentation.
The approach facilitates data visualization without occlusions.

Conclusions:

Surface-based methods provide a robust alternative to conventional hippocampal segmentation techniques.
Explicitly modeling hippocampal folding enhances interindividual alignment and subfield parcellation.
This approach overcomes limitations of current manual and registration-based methods in MRI analysis.