Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cycloalkanes02:28

Cycloalkanes

14.2K
Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
14.2K
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

3.2K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
3.2K
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.5K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.5K
Positive Regulator Molecules02:39

Positive Regulator Molecules

5.9K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.9K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

2.9K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
2.9K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

13.9K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
13.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prism[5]MaxQ: A Sulfated Prism[5]Arene and Its Molecular Recognition Properties Toward a Panel of Quaternary Ammonium Guests.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Acyclic cucurbituril as sequestrant for acetaminophen.

Chemical communications (Cambridge, England)·2026
Same authorSame journal

Molecular recognition properties of water-soluble Prism[5]arene towards drugs of abuse.

Supramolecular chemistry·2026
Same authorSame journal

Tetrachloroanthracene Walled Glycoluril Dimer Undergoes Self-Association and 1:1, 2:2, and 1:3 Host•Guest Binding.

Supramolecular chemistry·2026
Same author

Insoluble methylene-bridged glycoluril dimers as sequestrants for dyes.

Beilstein journal of organic chemistry·2025
Same author

Aromatic Wall Extension of Glycoluril-Derived Molecular Clips Enhances Binding of Planar Aromatic Dyes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same journal

Synthesis of tyramine bis(dipicolylamine), a versatile synthetic receptor scaffold for oxyanion recognition.

Supramolecular chemistry·2025
Same journal

Fluorescent cyclopropyl ester probes are efficiently cleaved by endogenous carboxylesterase in mouse blood: implications for preclinical fluorescence imaging.

Supramolecular chemistry·2025
Same journal

An updated synthesis of <i>octa</i>-acid.

Supramolecular chemistry·2025
Same journal

NASC 2023: Showcasing Diversity in North American Supramolecular Chemistry.

Supramolecular chemistry·2024
See all related articles

Related Experiment Video

Updated: Oct 26, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.9K

Acyclic Cucurbituril Featuring Pendant Cyclodextrins.

Ming Cheng1, Lyle Isaacs1

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.

Supramolecular Chemistry
|July 26, 2021
PubMed
Summary
This summary is machine-generated.

Researchers designed a new supramolecular host (H1) by combining cucurbit[n]uril and β-cyclodextrin. This chimeric host aims to improve binding affinity for guests like fentanyl, potentially leading to new antidotes for intoxication.

Keywords:
Cucurbit[n]urilcyclodextrinsfentanylmolecular recognitionsupramolecular antidotes

More Related Videos

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.0K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.4K

Related Experiment Videos

Last Updated: Oct 26, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.9K
Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

8.0K
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

2.4K

Area of Science:

  • Supramolecular Chemistry
  • Host-Guest Chemistry
  • Medicinal Chemistry

Background:

  • Acyclic cucurbit[n]urils (CB[n]) are known molecular hosts.
  • β-cyclodextrins (β-CD) are widely used complexing agents.
  • There is a need for enhanced receptors to bind challenging guests, such as fentanyl.

Purpose of the Study:

  • To design and synthesize an acyclic cucurbit[n]uril-β-cyclodextrin chimeric host (H1).
  • To deepen the receptor cavity for improved complexation of guest moieties.
  • To enhance binding affinity for potential supramolecular antidotes against fentanyl intoxication.

Main Methods:

  • Synthesis of chimeric hosts H1 and H2.
  • 1H NMR spectroscopy to determine complex geometry.
  • Isothermal titration calorimetry to ascertain thermodynamic parameters.

Main Results:

  • Chimeric host H1 was successfully synthesized and characterized.
  • 1H NMR and ITC confirmed complex formation between hosts H1/H2 and various guests, including fentanyl.
  • Host H1 exhibited slightly stronger binding than H2, though the reasons are unclear.
  • Dianionic hosts H1 and H2 were less potent than tetraanionic hosts M1 and M2, highlighting the role of electrostatic interactions.

Conclusions:

  • The study demonstrates the creation of a novel chimeric host with potential applications in supramolecular chemistry.
  • Binding affinity optimization for supramolecular antidotes presents inherent challenges.
  • Electrostatic interactions play a significant role in the binding efficacy of these host systems.