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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

477
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
477
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

264
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
576
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

444
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
444
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

291
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
291
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

465
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Updated: Oct 26, 2025

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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Crohn's Disease Obstructions.

Molly M Ford1

  • 1Department of General Surgery, Colon & Rectal Surgery, Nashville, Tennessee.

Clinics in Colon and Rectal Surgery
|July 26, 2021
PubMed
Summary
This summary is machine-generated.

Stricturing Crohn's disease often requires intervention due to obstruction. While inflammation responds to medication, chronic fibrosis necessitates further treatment, with surgery remaining crucial for inaccessible strictures.

Keywords:
Crohn's diseasebowel obstructionstricture

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Last Updated: Oct 26, 2025

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Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology

Background:

  • Obstruction from stricturing Crohn's disease is a common complication requiring medical or surgical intervention.
  • Acute inflammation in strictures may resolve with medication, but chronic fibrotic changes are refractory.

Purpose of the Study:

  • To review the role of surgery in managing obstructing Crohn's disease, considering current therapeutic options.

Main Methods:

  • Review of current literature on Crohn's disease strictures.
  • Analysis of treatment modalities including medical management, endoscopic balloon dilation, and surgical resection.

Main Results:

  • Endoscopic balloon dilation is effective for amenable strictures but has high recurrence rates.
  • Surgery remains a primary treatment for non-amenable or recurrent strictures in Crohn's disease.

Conclusions:

  • Surgical intervention remains a vital component in the management of obstructing Crohn's disease, particularly for fibrotic and inaccessible strictures.
  • While endoscopic therapies are advancing, they do not fully replace the role of surgery.