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Updated: Oct 26, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Recurrent pulmonary infections as the first presentation of Letterer Siwe disease
Leen Jamel Doya1, Ghazal Dib1, Fouz Hassan2
1Department of Pediatrics, Faculty of Medicine, Tishreen University Hospital, Lattakia, Syria.
Abstract:
Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology that affects several organs. The fatal type of Langerhans cell histiocytosis is called Letterer Siwe disease (LSD) which is multisystem with a poor prognosis. Herein, we report a 20-month-old male who was admitted for recurrent pulmonary infections at the age of 10 months. Diagnostic workup revealed a Letterer-Siwe disease. The patient was treated with a good response.
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