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Management of Refractory Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia with Bevacizumab

Muaaz Masood1, Michael Coles1, Humberto Sifuentes2

  • 1Department of Internal Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

Case Reports in Gastrointestinal Medicine
|July 26, 2021
PubMed

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder resulting in vascular malformations of several organs including the pulmonary, cerebral, and gastrointestinal systems. One sequela is recurrent gastrointestinal (GI) bleeding. Bevacizumab (Bev) is emerging as an effective treatment of recurrent gastrointestinal bleeding in HHT. Bev is a recombinant monoclonal antibody that inhibits vascular endothelial growth factor (VEGF), an integral part of angiogenesis.

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