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Updated: Oct 26, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Protein-Based Nanohydrogels for Bioactive Delivery.

Subhash Chander¹, Giriraj T Kulkarni^2,3, Neerupma Dhiman²

¹Amity Institute of Phytochemistry and Phytomedicine, Amity University, Noida, India.

Frontiers in Chemistry

|July 26, 2021

Summary

This summary is machine-generated.

Protein nanohydrogels are versatile biomaterials with tunable properties. This review explores their preparation, characteristics, and applications in drug delivery, regenerative medicine, and wound healing.

Keywords:

biodegradability drug delivery nanohydrogels natural protein polymeric networks self-assembly

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Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Hydrogels are 3D polymer networks that absorb significant fluid.
Nanohydrogels (NGs) are nanoscale hydrogels derived from synthetic or natural polymers.
Protein/peptide-based NGs offer biocompatibility and biodegradability.

Purpose of the Study:

To review protein/peptide nanohydrogels.
To analyze their preparation, biophysiochemical properties, and applications.
To discuss clinical potential, limitations, and future directions.

Main Methods:

Exploration of various protein sources (fibroin, albumin, collagen, etc.).
Discussion of fabrication techniques (emulsion, electrospray, desolvation).
Analysis of stimuli-responsive properties (pH, temperature, ionic concentration).

Main Results:

Protein NGs exhibit tunable mechanical strength and molecular binding.
Applications span drug delivery, immunotherapy, cell adhesion, and wound dressing.
Naturally occurring structural proteins are key components.

Conclusions:

Protein nanohydrogels are promising biomaterials for diverse biomedical applications.
Further research is needed to address toxicity, stability, and clinical translation.
Their biocompatibility and biodegradability highlight significant therapeutic potential.