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Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case.
Dimitris Dimopoulos1, Andreas Zacharioudakis1, Georgios Kazamias2
1Opthalmology Department,"Venizeleio" General Hospital of Heraklion, Heraklion, Greece.
European Journal of Ophthalmology
|July 26, 2021
Summary
Ligneous conjunctivitis, a rare eye condition, was diagnosed in a patient with severe plasminogen deficiency. Topical treatments, including fresh frozen plasma, were effective in managing this chronic condition.
Area of Science:
- Ophthalmology
- Hematology
- Genetics
Background:
- Ligneous conjunctivitis is a rare, chronic condition presenting with woody pseudomembranes.
- It is often linked to congenital plasminogen deficiency, an autosomal recessive disorder.
- This deficiency impacts wound healing due to mutations in the PLG gene and other related genes.
Observation:
- A 36-year-old female presented with eye redness, irritation, and membranous lesions.
- Biomicroscopy revealed thick, yellowish-white pseudomembranes and conjunctival proliferation with ligneous induration on the upper eyelids.
Findings:
- Histopathology confirmed ligneous conjunctivitis.
- Laboratory tests revealed severe plasminogen deficiency (PLG < 2%).
Implications:
- This case highlights the association between ligneous conjunctivitis and severe plasminogen deficiency.
- Topical treatment with fresh frozen plasma, steroids, heparin, and artificial tears showed efficacy without systemic therapy.
- Further research into plasminogen deficiency and its ocular manifestations is warranted.
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