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Related Concept Videos

Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Oct 26, 2025

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
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Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.

Marie Weinreich Petersen1, Sine Skovbjerg2,3, Jens Søndergaard Jensen1

  • 1Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

European Journal of Pain (London, England)
|July 26, 2021
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Summary

This study found no strong evidence of altered pain regulation in functional somatic disorders (FSD) within a general population. Findings challenge the hypothesis that abnormal pain sensitivity is a core mechanism in FSD.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Epidemiology

Background:

  • Functional somatic disorders (FSD) are hypothesized to involve disrupted pain regulation.
  • Clinical observations suggest hypersensitivity in FSD patients.
  • This study investigates pain sensitivity and modulation in a population-based FSD sample.

Purpose of the Study:

  • To examine pain sensitivity and conditioning pain modulation (CPM) in a general population sample with FSD.
  • To assess associations between FSD delimitations, pain thresholds, and CPM.
  • To test the hypothesis of altered pain regulation in FSD.

Main Methods:

  • Assessed pressure pain thresholds (PPTs) and CPM in 2,198 Danish adults.
  • FSD was determined using self-reported symptom questionnaires.
  • PPTs were measured at tibialis and trapezius muscles; CPM involved cold pressor stimulation.

Main Results:

  • Weak associations were found between PPTs/CPM and FSD, with few exceptions.
  • High PPTs were linked to lower odds of multi-organ distress and specific symptom profiles.
  • High CPM was associated with higher odds of irritable bowel syndrome.

Conclusions:

  • Population-based findings do not support altered pain regulation in questionnaire-defined FSD.
  • The hypothesis of abnormal pain sensitivity as a central FSD mechanism is not supported by this study.
  • Further epidemiological research is needed to explore FSD pathophysiology.