Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Building the boat while sailing" - adapting towards telementoring literacy.

BMC medical education·2026
Same author

Histotripsy for Liver Tumor Ablation and Beyond: <i>AJR</i> Expert Panel Narrative Review.

AJR. American journal of roentgenology·2026
Same author

Focused ultrasound as a therapeutic adjunct in pancreatic cancer: from thermal and mechanical effects to immune modulation.

Ultrasonography (Seoul, Korea)·2026
Same author

Quality and safety of research biopsies in oncology clinical trials.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Safety and Efficacy of Histotripsy Treatments Near Implanted Metallic Fiducials and Endovascular Coils in Phantoms and in an In Vivo Swine Model.

Ultrasound in medicine & biology·2026
Same author

Histotripsy for neuroendocrine liver metastases: Early single-institution outcomes and safety.

Surgery·2026

Related Experiment Video

Updated: Oct 26, 2025

Thermal Ablation for the Treatment of Abdominal Tumors
07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

34.8K

Liver Histotripsy Mediated Abscopal Effect-Case Report.

Joan Vidal-Jove, Xavier Serres-Creixams, Timothy J Ziemlewicz

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |July 26, 2021
    PubMed
    Summary
    This summary is machine-generated.

    This case report demonstrates an abscopal effect from histotripsy, a noninvasive liver tumor ablation technique. Patients experienced reduced non-treated tumor volumes and sustained decreases in carcinoembryonic antigen (CEA) levels post-procedure.

    More Related Videos

    Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
    04:22

    Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

    Published on: March 3, 2023

    610
    Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
    04:41

    Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy

    Published on: March 10, 2023

    1.4K

    Related Experiment Videos

    Last Updated: Oct 26, 2025

    Thermal Ablation for the Treatment of Abdominal Tumors
    07:16

    Thermal Ablation for the Treatment of Abdominal Tumors

    Published on: March 7, 2011

    34.8K
    Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
    04:22

    Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

    Published on: March 3, 2023

    610
    Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
    04:41

    Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy

    Published on: March 10, 2023

    1.4K

    Area of Science:

    • Oncology
    • Medical Physics
    • Immunology

    Background:

    • Histotripsy is a novel noninvasive, nonthermal, and nonionizing precise ablation technique for tissue destruction guided by ultrasonography.
    • Clinical trials are evaluating histotripsy's safety and efficacy for liver tumor ablation.
    • The abscopal effect, a rare phenomenon where treatment of one tumor leads to shrinkage of distant, non-treated tumors, is being investigated.

    Observation:

    • A case report within a histotripsy clinical trial for liver tumors observed an abscopal effect.
    • The effect manifested as a reduction in the volume of non-treated tumor lesions within the same organ.
    • Sustained reduction of the tumor marker carcinoembryonic antigen (CEA) was noted, extending weeks beyond the procedure.

    Findings:

    • Histotripsy treatment induced an abscopal effect in a patient with liver tumors.
    • The observed abscopal effect included shrinkage of untreated tumor lesions and a decrease in CEA levels.
    • The noninvasive nature of histotripsy makes it a potentially advantageous focal therapy.

    Implications:

    • Histotripsy may possess immunomodulatory properties, contributing to the abscopal effect.
    • This technique shows potential as an immune system enhancer in cancer treatment.
    • Further research is warranted to explore histotripsy's role in immunotherapy and its comparison to other focal therapies.