Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.3K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.3K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

5.1K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
5.1K
Bone Disorders01:29

Bone Disorders

4.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.4K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

57
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
57
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

41
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
41
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

45
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
45

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric Allergy: An Overview.

Primary care·2021
Same author

An Unexpected Case of Lisinopril-Associated Severe Hyponatremia.

Cureus·2020
Same author

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.

Neuropharmacology·2017
See all related articles

Related Experiment Video

Updated: Oct 26, 2025

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
06:52

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

54.1K

Common Pediatric Musculoskeletal Issues.

Brittney M Richardson1, Meghane E Masquelin2

  • 1Department of Family and Geriatric Medicine, University of Louisville School of Medicine, 215 Central Avenue, Suite 205, Louisville, KY 40208, USA.

Primary Care
|July 27, 2021
PubMed
Summary

This review covers common injuries in active children, focusing on overuse injuries and back disorders. It provides guidance for primary care management of pediatric sports injuries.

Keywords:
Apophyseal injuryBack painImagingMusculoskeletalPediatricPhyseal injuryTherapies

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

24.8K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.8K

Related Experiment Videos

Last Updated: Oct 26, 2025

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
06:52

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

54.1K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

24.8K
A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.8K

Area of Science:

  • Pediatric Sports Medicine
  • Adolescent Musculoskeletal Health

Background:

  • Active children and adolescents are susceptible to various injuries.
  • Overuse injuries, physeal/apophyseal injuries, and adolescent back disorders are prevalent.
  • Effective outpatient management is crucial for pediatric patient recovery.

Purpose of the Study:

  • To review common injuries in active pediatric patients.
  • To discuss presentations, diagnostics, treatments, and prevention strategies.
  • To offer guidance for outpatient primary care management.

Main Methods:

  • Review of current literature on pediatric overuse injuries.
  • Discussion of physeal and apophyseal injuries in skeletally immature athletes.
  • Analysis of common back disorders in adolescents.

Main Results:

  • Common presentations and diagnostic criteria for pediatric injuries are outlined.
  • Treatment modalities for overuse injuries and back disorders are discussed.
  • Prevention strategies for active pediatric patients are highlighted.

Conclusions:

  • Primary care physicians can effectively manage many common pediatric sports injuries.
  • Emphasis on early diagnosis and appropriate management improves outcomes.
  • This review provides a framework for outpatient care of active pediatric patients.