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Related Experiment Video

Updated: Oct 26, 2025

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
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Macrophages on the margin: choroid plexus immune responses.

Jin Cui1, Huixin Xu1, Maria K Lehtinen1

  • 1Department of Pathology, Boston Children's Hospital, Boston, MA, USA.

Trends in Neurosciences
|July 27, 2021
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Summary

The choroid plexus (ChP) houses immune cells, particularly macrophages, influencing the blood-cerebrospinal fluid barrier (BCSFB). Their roles in neurodevelopmental disorders and CNS immune cell entry are key research areas.

Keywords:
blood–cerebrospinal fluid barrierborder-associated macrophageschoroid plexusneurodevelopmental psychiatric disordersneuroimmune functions

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Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • The choroid plexus (ChP) forms the blood-cerebrospinal fluid barrier (BCSFB), crucial for CNS homeostasis.
  • It is a site of significant immune cell activity, regulating immune cell entry into the central nervous system (CNS).

Purpose of the Study:

  • To review recent findings on choroid plexus immune cells, focusing on macrophages.
  • To explore the implications of these immune cells for BCSFB function and neurodevelopmental disorders.

Main Methods:

  • Literature review of recent studies on choroid plexus immune cells.
  • Analysis of ontogeny, development, and behavior of choroid plexus macrophages.

Main Results:

  • Choroid plexus macrophages are principal resident immune cells with significant roles.
  • Immune cells impact BCSFB integrity, cerebrospinal fluid (CSF) regulation, and cytokine profiles.

Conclusions:

  • Choroid plexus immune cells, especially macrophages, are critical for CNS health.
  • Dysregulation of these cells may contribute to neurodevelopmental disorders, with potential age-specific variations.