Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.0K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.0K
Human Genetics01:28

Human Genetics

905
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
905
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

675
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
675
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

6.4K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
6.4K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.8K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chest and Abdominal Wall Mobility and Cardiac Size in Older Adults With Heart Failure and Restrictive Spirometric Patterns: A Preliminary Cross-Sectional Study.

Cureus·2026
Same author

Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.

Nature communications·2026
Same author

Author Correction: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Nature communications·2026
Same author

Asian diversity in human immune cells.

Cell·2025
Same author

Relationship Between One-Leg Standing and Foot Sole Sensation Following Short-Term Immobilization of a Unilateral Lower Extremity.

Cureus·2025
Same author

Blood DNA virome associates with autoimmune diseases and COVID-19.

Nature genetics·2025

Related Experiment Video

Updated: Oct 26, 2025

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
18:08

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

10.1K

Functional genetics for studying the human immune system.

Kazuhiko Yamamoto1, Akari Suzuki1, Matteo Maurizio Guerrini1

  • 1Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

International Immunology
|July 27, 2021
PubMed
Summary

Most immune-mediated diseases arise from genetic and environmental factors. Understanding functional genetics in human immunology, particularly autoimmune diseases, is key for developing new drugs.

Keywords:
autoimmune diseasesgenetic factorsgenome functiongenome-wide association analysishuman immunology

More Related Videos

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

3.4K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

14.8K

Related Experiment Videos

Last Updated: Oct 26, 2025

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
18:08

Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation

Published on: December 31, 2007

10.1K
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

3.4K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

14.8K

Area of Science:

  • Immunology
  • Genetics
  • Pathogenesis

Background:

  • Immune-mediated diseases are often multifactorial, involving genetic and environmental influences.
  • Genome-wide association studies (GWAS) have identified numerous disease-susceptibility genes and variants.
  • Gene expression levels and cell-type-specific epigenome alterations are linked to disease pathogenesis.

Purpose of the Study:

  • To review the role of functional genetics in understanding human immune system diseases.
  • To focus on autoimmune diseases and their pathogenesis.
  • To discuss current and future directions in immune system research for drug discovery.

Main Methods:

  • Review of existing literature on immune-mediated diseases.
  • Analysis of genome-wide association studies (GWAS) findings.
  • Examination of the relationship between genetic variants, gene expression, and epigenome alterations.

Main Results:

  • Genetic and environmental factors contribute to multifactorial immune-mediated diseases.
  • Disease-susceptibility variants often correlate with altered gene expression.
  • Epigenome alterations play a role in cell-type-specific gene expression during disease.

Conclusions:

  • Establishing functional genetics in human immunology is crucial for understanding disease pathogenesis.
  • Genomic information offers insights into disease causality and outcomes.
  • Research in human immunology holds potential for novel drug discovery and therapeutic strategies.