Acquired Vitelliform-Like Lesion in Uveitis: A case-series

Area of Science:

• Ophthalmology
• Medical Retina
• Uveitis

Background:

• Acquired vitelliform-like lesions (AVLL) are a recognized ophthalmic finding.
• Understanding the role of AVLL in uveitis is crucial for patient management.
• The diagnostic and prognostic implications of AVLL in uveitis require further elucidation.

Purpose of the Study:

• To investigate acquired vitelliform-like lesions (AVLL) in the context of uveitis.
• To determine the diagnostic value of AVLL in uveitis.
• To assess the prognostic significance of AVLL in uveitis patients.

Main Methods:

• Retrospective case series comparing uveitis patients with and without AVLL.
• Analysis of clinical course, diagnostic indicators, and prognostic factors.
• Inclusion of 12 patients (21 eyes) with uveitis and AVLL, and 13 patients (24 eyes) without AVLL.

Main Results:

• The AVLL group showed significantly higher rates of macular leakage, vasculitis, active choroiditis, and cystoid macular edema (CME) on OCT.
• Best-corrected visual acuity was significantly lower at presentation and final follow-up in the AVLL group.
• Statistical significance was observed for macular leakage (p=.005), vasculitis (p=.01), active choroiditis (p=.01), CME on OCT (p=.008), initial visual acuity (p<.001), and final visual acuity (p=.014).

Conclusions:

• Acquired vitelliform-like lesions possess both diagnostic and prognostic value in uveitis.
• AVLL can aid in the differential diagnosis of uveitis.
• The presence of AVLL suggests a potentially poorer visual prognosis in uveitic eyes.