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Updated: Oct 26, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

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Imidazolidine Derivatives in Cancer Research: What is known?

Auvani Antunes da Silva Júnior1, Marina Galdino da Rocha Pitta1, Mardonny Bruno de Oliveira Chagas2

  • 1Department of Therapeutic innovation, Federal University of Pernambuco, Recife, Brazil.

Anti-Cancer Agents in Medicinal Chemistry
|July 28, 2021
PubMed

Insights

Imidazolidine derivatives show promise in cancer therapy by regulating cell cycles and DNA stability. This review highlights their role in modulating cancer progression and malignancy based on recent research.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Molecular Biology

Background:

  • Cancer is a leading global cause of death, necessitating novel therapeutic strategies.
  • Imidazolidine derivatives are recognized for their potential in cancer treatment.
  • These compounds possess a heterocyclic nucleus that facilitates direct DNA interaction.

Purpose of the Study:

  • To review the role of imidazolidine derivatives in current cancer therapy.
  • To explore the future potential of imidazolidines in cancer prognosis and treatment.
  • To consolidate evidence on imidazolidines' efficacy in modulating cancer progression.

Main Methods:

  • Literature review of studies from 1996 to 2021.
  • Analysis of in vitro and in vivo experimental data.
  • Examination of imidazolidine derivatives across various cancer cell lines and types.

Main Results:

  • Imidazolidine derivatives demonstrate the ability to regulate cell cycle progression.
  • These compounds contribute to maintaining DNA stability.
  • Evidence supports their role in modulating cancer malignancy and progression.

Conclusions:

  • Imidazolidine derivatives represent a significant therapeutic tool for cancer management.
  • Their mechanism involves direct DNA interaction, influencing replication and stability.
  • Future research can further leverage imidazolidines for improved cancer prognosis and treatment outcomes.
Keywords:
ApoptosisDNAanticancercancercell cycleimidazolidine

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