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Updated: Oct 26, 2025
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Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
Published on: May 2, 2016
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Gold Nanorods are Selective Cytotoxic Agents
Mohamed El Gendy1, Michael Weinfeld2, Ahmed Abdoon3
1Drug Bioassay-Cell Culture Laboratory, Department of Pharmacognosy, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt.
Anti-Cancer Agents in Medicinal Chemistry
|July 28, 2021
Summary
Gold nanorods (GNRs) show selective toxicity against various cancer cells, with 25-nm GNRs demonstrating potential as anticancer agents. Further research is warranted to explore their therapeutic applications.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Cancer Research
Background:
- Gold nanorods (GNRs) are promising for medical and biological applications.
- The cytotoxic effects of GNRs require further investigation.
Purpose of the Study:
- To determine the selective cytotoxic effects of different GNR sizes on human tumor cell lines.
- To evaluate GNRs' potential as anticancer agents.
Main Methods:
- Tested three GNR sizes (10-nm, 25-nm, 50-nm) against HepG2 and PC3 cancer cells.
- Assessed GNR cytotoxicity on murine splenocytes and a panel of 11 tumor and 2 non-tumor cell lines.
- Utilized colony formation assays and cell cycle analysis.
Main Results:
- 25-nm GNRs exhibited selective cytotoxicity against PC3, HL60, HeLa, 786.0, and HepG2 cancer cells.
- High selectivity indices were observed for PC3 and HL60 cells.
- Laser treatment potentiated the cytotoxic effect of 25-nm GNRs.
Conclusions:
- Gold nanorods (GNRs) demonstrate selective cytotoxic properties against cancer cells.
- GNRs hold potential as candidate anticancer agents.
