Myocardial and Pericardial Toxicity Associated With Immune Checkpoint Inhibitors in Cancer Patients
Johnny Chahine1, Patrick Collier2, Anjli Maroo3
1Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.
JACC. Case Reports
|July 28, 2021
Summary
Immune checkpoint inhibitors can cause cardiac side effects, including cardiomyopathies and pericarditis, in 0.3% of patients. This study details their presentation and outcomes in a single center.
Area of Science:
- Cardiology
- Oncology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) revolutionized cancer treatment.
- Immunity-related adverse effects (irAEs) are known complications of ICIs.
- Cardiac irAEs are rare but potentially severe complications.
Observation:
- A single center reviewed 2,830 patients treated with ICIs.
- Nine patients (0.3%) developed cardiac irAEs.
- Manifestations included cardiomyopathies, myocarditis, acute pericarditis, and pericardial effusion.
Findings:
- Detailed case reports describe disease profiles and hospital courses.
- Outcomes varied among the affected patients.
- Early recognition and management are crucial for patient outcomes.
Implications:
- This highlights the importance of cardiac monitoring in patients receiving ICIs.
- Understanding cardiac irAEs aids in clinical decision-making and patient counseling.
- Further research is needed to elucidate mechanisms and optimize treatment strategies.
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