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Updated: Oct 26, 2025

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A Complex Tricuspid Clip: Bridging the Decision.

Devang S Parikh1, Sarah Blissett1, Kirsten Tolstrup1

  • 1Department of Medicine, University of California-San Francisco, San Francisco, California.

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|July 28, 2021
PubMed
Summary
This summary is machine-generated.

This case study highlights a 22-year-old woman, the youngest reported, successfully treated for severe tricuspid regurgitation using the MitraClip system. This advanced treatment complements standard therapies for complex congenital heart disease.

Keywords:
RV, right ventricleTR, tricuspid regurgitationcardiomyopathychronic heart failureechocardiographyrestrictivetricuspid valvevalve repair

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Congenital Heart Disease

Background:

  • Tricuspid regurgitation (TR) is a significant complication in patients with congenital heart disease.
  • Medically refractory TR poses a therapeutic challenge, particularly in younger patients.
  • Guideline-directed medical therapy (GDMT) may be insufficient for severe TR.

Observation:

  • A 22-year-old woman with congenital heart disease presented with medically refractory torrential tricuspid regurgitation.
  • This patient represents the youngest reported case undergoing successful MitraClip system intervention for severe TR.
  • The patient's condition was refractory to maximal medical management.

Findings:

  • Successful treatment of torrential tricuspid regurgitation was achieved using the MitraClip system.
  • The MitraClip procedure served as an adjunct to guideline-directed therapy.
  • The intervention was technically successful with favorable acute outcomes.

Implications:

  • The MitraClip system offers a viable treatment option for severe, refractory TR in young adults with congenital heart disease.
  • This case expands the evidence for transcatheter tricuspid valve repair in complex adult congenital heart disease.
  • Further research is warranted to evaluate long-term outcomes and expand indications for this approach.