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[Value of blood creatinine in children]
M Nicolino1, P Cochat, B Saraidarian
1Service de pédiatrie, Hôpital Edouard-Herriot, Lyon, France.
Insights
This study establishes normal serum creatinine values for children aged 3 months to 12 years. These age-dependent levels are comparable to standardized methods and accurately estimate kidney function in pediatric patients.
Area of Science:
- Pediatric Nephrology
- Clinical Chemistry
Context:
- Serum creatinine is a key indicator of kidney function.
- Standardized reference ranges are crucial for accurate pediatric diagnosis.
- Previous studies often lacked comprehensive age-specific data for serum creatinine.
Purpose:
- To establish age-dependent normal serum creatinine values in children.
- To compare non-standardized values with existing literature.
- To validate serum creatinine as a reliable marker for glomerular filtration rate estimation in pediatric populations.
Summary:
- Serum creatinine levels were analyzed in 205 hospitalized children (3 months to 12 years) with mild illnesses and no prior renal impairment.
- The non-standardized values obtained were comparable to those reported using standardized methods.
- A graphic representation of normal age-dependent serum creatinine (mean +/- 2 SD) was developed, showing a clear increase with age.
Impact:
- Provides essential reference ranges for pediatric serum creatinine.
- Facilitates more accurate assessment of kidney function in children.
- Supports the use of serum creatinine for estimating glomerular filtration rate in pediatric care.
Abstract:
Non-standardized values of serum creatinine are studied in 205 children aged 3 months to 12 years. Data are collected from paediatric patients hospitalised for mild illness without previous renal impairment; these values are quite comparable to those related in the literature based or standardised methods. The normal age-dependent serum creatinine values (mean +/- 2 SD) are shown in a graphic curve, which confirms that serum creatinine increases with age and that it is a faithful parameter to estimate the glomerular filtration rate in children.