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Determination of atropine in plasma by a direct radioreceptor assay
K Ensing1, R A De Zeeuw, U Hörnchen
1State University of Groningen, Groningen Centre for Drug Research, The Netherlands.
Pharmaceutisch Weekblad. Scientific Edition
|December 11, 1987
Abstract:
A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs.