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Related Concept Videos

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Imaging Studies II: Ultrasonography

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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Related Experiment Video

Updated: Oct 26, 2025

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
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Equivalent time active cavitation imaging.

Simon Blais1, Jonathan Porée1, Gerardo Ramos-Palacios2

  • 1Engineering Physics Department, Polytechnique Montréal, Canada.

Physics in Medicine and Biology
|July 28, 2021
PubMed
Summary
This summary is machine-generated.

A new ultrasound imaging method, equivalent time active cavitation imaging (ETACI), can actively map the high-intensity focused ultrasound (HIFU) pressure field. This technology enables precise monitoring of HIFU blood-brain barrier opening, improving treatment safety and efficacy.

Keywords:
blood-brain barrier openingcavitationmonitoringpressure mappingultrafast ultrasound imaging

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Real-time Monitoring of High Intensity Focused Ultrasound HIFU Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound HMIFU
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Area of Science:

  • Biomedical Engineering
  • Ultrasound Imaging
  • Neuroscience

Background:

  • Drug delivery to the brain is hindered by the blood-brain barrier (BBB), limiting treatment options for neurological diseases.
  • High-intensity focused ultrasound (HIFU) offers site-specific BBB opening, expanding therapeutic possibilities.
  • Current monitoring methods for HIFU treatments lack active, spatiotemporal mapping of the pressure field, risking brain damage.

Purpose of the Study:

  • To develop and validate a novel ultrasound imaging modality for active and spatiotemporal mapping of the HIFU pressure field.
  • To enable precise monitoring during HIFU-induced BBB opening procedures.

Main Methods:

  • Development of equivalent time active cavitation imaging (ETACI), an ultrafast active ultrasound imaging technique.
  • Implementation of a novel plane wave sequence with linearly increasing transmit delays for high-frequency cavitation event sampling.
  • Algorithm development for processing microbubble signals to map the pressure field, validated in vitro and in vivo.

Main Results:

  • ETACI successfully characterized the HIFU pressure field spatiotemporally using stable cavitation events.
  • In vitro pressure field mapping showed good correlation with hydrophone measurements.
  • Promising in vivo results were obtained during blood-brain barrier opening in mice.

Conclusions:

  • This proof-of-concept study establishes ETACI as a novel ultrasound modality for monitoring HIFU BBB opening.
  • ETACI offers a safe and precise method for real-time monitoring, paving the way for advanced neurotherapeutics.