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Updated: Sep 11, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

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3D Transcranial Dynamic Ultrasound Localization Microscopy in the Mouse Brain Using a Row-Column Array.

Alice Wu, Jonathan Poree, Gerardo Ramos-Palacios

IEEE Transactions on Bio-Medical Engineering

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Summary

This study introduces 3D transcranial Dynamic Ultrasound Localization Microscopy (DULM) using a Row-Column Array (RCA) for high-resolution brain blood flow imaging. The technique successfully mapped pulsatile flow in mice, showing higher arterial than venous pulsatility.

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Last Updated: Sep 11, 2025

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Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

Area of Science:

Neuroimaging
Biomedical Engineering
Cardiovascular Research

Background:

Current imaging methods lack the resolution for detailed brain hemodynamics.
Understanding cerebral blood flow is crucial for neurodegenerative disease research.
Limitations in spatial and temporal resolution hinder quantitative flow mapping.

Purpose of the Study:

To demonstrate the feasibility of 3D transcranial Dynamic Ultrasound Localization Microscopy (DULM).
To enable high spatiotemporal resolution blood flow measurements in the brain.
To overcome limitations of 2D imaging for velocity estimation in complex vasculature.

Main Methods:

Utilized a (128+128)-element, 12 MHz Row-Column Array (RCA) for transcranial DULM.
Acquired images at a 750-Hz volume rate using tilted plane waves and microbubble tracking.
Developed super-resolved dynamic density and velocity maps of the 3D brain vascular network.

Main Results:

Successfully observed and mapped pulsatile blood flow in the brains of 7 anesthetized mice.
Demonstrated significantly higher pulsatility in cortical arteries compared to veins.
Results were consistent across all subjects and aligned with existing literature.

Conclusions:

This study confirms the feasibility and reproducibility of 3D transcranial DULM with RCA for mouse brain vasculature imaging.
Highlights the potential of RCA 3D DULM for non-invasive cerebral hemodynamics studies.
Suggests applicability for early-stage neurodegenerative disease research requiring comprehensive vascular imaging.