Dental Management of Siblings with GAPO Syndrome

GAPO syndrome is a rare autosomal recessive genetic disorder, characterized by growth retardation, alopecia, pseudoanodontia, and progressive ocular changes. This disorder is caused by recessive mutations in the ANTXR1 gene and has characteristic dysmorphic facial features along with connective tissue changes, cardiomyopathy, gonadal dysfunction and craniosynostosis. The most common dental implication of GAPO syndrome is pseudoanodontia caused by eruption failure of the primary and permanent dentition. Currently, there is no standard treatment for patients with GAPO syndrome. Management often includes multidisciplinary care in the surveillance of syndromic sequelae and supportive treatment of symptomatic health concerns, which are unique to each patient. The purpose of this paper is to describe the dental rehabilitation of two brothers with GAPO syndrome.