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A Case-Cohort Study of Exfoliation Risk Factors and Literature Review
Ahmad M Mansour1,2, Anastasios G P Konstas3, Hana A Mansour1
1Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
Middle East African Journal of Ophthalmology
|July 29, 2021
Summary
This study identifies habitual eye rubbing as a significant risk factor for exfoliation syndrome (XFS), a condition affecting cataract surgery patients. Managing ocular surface disorders is crucial for patients with XFS.
Area of Science:
- Ophthalmology
- Genetics and Hereditary Diseases
Background:
- Exfoliation syndrome (XFS) is a condition that can complicate cataract surgery.
- Identifying risk factors for XFS is crucial for patient management and surgical planning.
Purpose of the Study:
- To evaluate risk factors associated with exfoliation syndrome (XFS) in a case-cohort setting.
- To investigate the correlation between ocular and systemic variables and XFS.
Main Methods:
- A prospective, single-center case-cohort study was conducted from January 2010 to April 2020.
- 49 patients with XFS and 62 controls undergoing cataract surgery were analyzed.
- Systemic and ocular variables, including eye rubbing, were assessed.
Main Results:
- Patients with XFS had significantly poorer baseline visual acuity and denser nuclear sclerosis.
- Univariate analysis revealed associations between XFS and allergic conjunctivitis, dry eye, and habitual eye rubbing.
- Multivariable analysis identified glaucoma, longer surgery duration, and habitual eye rubbing as significant risk factors for XFS.
Conclusions:
- Habitual eye rubbing is a novel potential risk factor for exfoliation syndrome (XFS).
- Chronic eye rubbing may induce or worsen zonular damage in XFS patients.
- Better management of ocular surface disorders is recommended for patients with XFS.
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