Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation...

Area of Science:

• Neuroscience
• Biomedical Engineering
• Computational Neuroscience

Background:

• Closed-loop neurostimulation is a rapidly advancing therapy for neurological and psychiatric disorders.
• Chronic implantation of bidirectional devices like the Medtronic Summit RC+S system generates complex neural data.
• Optimizing neurostimulation requires offline analysis of recorded neural data to refine sensing and stimulation parameters.

Purpose of the Study:

• To develop an open-source toolbox for processing raw data from the Medtronic Summit RC+S system.
• To facilitate time-frequency analyses and modeling of neural data for therapeutic optimization.
• To accelerate research and clinical translation of adaptive neurostimulation.

Main Methods:

• Development of a MATLAB-based open-source toolbox.
• Implementation of data conversion, parsing, and time reconstruction functionalities.
• Inclusion of a plotting tool for visualizing multi-stream data and device settings.
• Integration of an analysis module for replicating on-board power computations.

Main Results:

• The toolbox transforms raw Summit RC+S files into a standardized format suitable for conventional neuroscientific analyses.
• A plotting tool aids in visualizing complex data streams and device parameters.
• An analysis module enables accelerated biomarker discovery through power computation replication.

Conclusions:

• The developed toolbox standardizes complex neural data, making it accessible for advanced analysis.
• This resource is expected to accelerate research and clinical applications of closed-loop neurostimulation.
• The toolbox supports the advancement of adaptive neurostimulation for patients with neurological and psychiatric conditions.