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WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related

Huan Ren1,2,3,4, Jian-Quan Luo5, Fan Ouyang6

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Cardiovascular Medicine
|July 29, 2021
PubMed

Insights

A genetic variant in the WNT3A gene, rs752107, is strongly linked to increased risks of essential hypertension (EH), heart failure (HF), and ischemic stroke (IS). This finding highlights the Wnt/β-catenin signaling pathway

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Signaling Pathways

Background:

  • Essential hypertension (EH) contributes significantly to cardiovascular disease (CVD) burden, including heart failure (HF) and ischemic stroke (IS).
  • The Wnt/β-catenin signaling pathway is increasingly recognized for its critical roles in cardiovascular development and function.
  • Genetic variations within this pathway may influence susceptibility to cardiovascular conditions.

Purpose of the Study:

  • To investigate the association between genetic variants in the Wnt/β-catenin signaling pathway and the risk of EH, HF, and IS.
  • To identify specific single nucleotide polymorphisms (SNPs) associated with these cardiovascular diseases.

Main Methods:

  • Genotyping of 95 SNPs across 12 Wnt signaling pathway genes in 1,860 participants (including patients with EH, HF, IS, and controls).
  • Utilized Sequenom MassArray technology for SNP genotyping.
  • Performed expression quantitative trait loci (eQTL) analysis to correlate genotype with gene expression.

Main Results:

  • The WNT3A rs752107 (C > T) variant showed a strong association with increased risk for EH, HF, and IS.
  • Carriers of the CT genotype had a 48% increased risk of EH, while TT genotype carriers had a 139% increased risk.
  • The T allele of rs752107 was associated with a 58% increased risk of HF and a 37% increased risk of IS. eQTL analysis showed the C allele reduced WNT3A expression.

Conclusions:

  • A specific genetic variant (rs752107) in the WNT3A gene within the Wnt/β-catenin signaling pathway is significantly associated with increased risk of EH, HF, and IS.
  • This study provides novel insights into the genetic underpinnings of cardiovascular diseases related to Wnt/β-catenin signaling.
  • The rs752107 variant may serve as a potential genetic biomarker for cardiovascular risk assessment.

Keywords:
Wnt3aessential hypertensiongenetic polymorphismsheart failureischemic stroke

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