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Tiny golden angle ultrashort echo-time lung imaging in mice.

Anke Balasch1, Patrick Metze1, Hao Li2,3

  • 1Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.

NMR in Biomedicine
|July 29, 2021
PubMed
Summary

This study introduces a novel 2D tiny golden angle (tyGA) ultrashort echo-time (UTE) MRI technique for high-resolution lung imaging in mice. The method enables reliable quantification of lung morphology and function, overcoming previous imaging challenges.

Keywords:
2D UTE, fractional ventilation, lung, lung density, MRI, perfusion, self-gating, T2*, tiny golden angle

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Small Animal Research

Background:

  • Magnetic Resonance Imaging (MRI) of small animal lungs is challenging due to high physiological rates and magnetic field effects.
  • Ultrashort T2* decay in lung parenchyma necessitates specialized MRI techniques.

Purpose of the Study:

  • To develop and validate a novel 2D ultrashort echo-time (UTE) MRI technique combined with tiny golden angle (tyGA) ordering for high-quality lung imaging in mice.
  • To assess the reproducibility of quantitative lung parameters derived from this technique.

Main Methods:

  • A 2D tyGA UTE sequence was implemented on a 11.7T MRI scanner.
  • Continuous data acquisition with retrospective respiratory gating was used for image reconstruction.
  • Lung proton density (fP), T2*, signal-to-noise ratio (SNR), fractional ventilation (FV), and perfusion (f) were quantified.
  • Dynamic contrast agent (CA)-enhanced (DCE) perfusion was qualitatively assessed.

Main Results:

  • High-quality lung parenchyma images were acquired in all subjects.
  • Mean T2* was measured at 0.20 ± 0.05 ms.
  • Fractional ventilation (FV) was 0.31 ± 0.13.
  • A trend of lower SNR during inspiration and a significant decrease in lung density were observed.
  • Quantitative perfusion values were obtained, and CA dynamics were assessed.
  • Good to excellent interobserver and excellent intraobserver reproducibility were achieved, with fair to good interstudy reproducibility.

Conclusions:

  • The 2D tyGA UTE technique provides reliable imaging of mouse lung morphology and function.
  • This method offers uniform k-space coverage, resulting in low-artifact images after gating.
  • The technique is suitable for quantitative assessment and dynamic studies of the lung parenchyma.