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Updated: Oct 26, 2025

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Cardiac structural and functional abnormalities in primary hyperparathyroidism.

S Purra1, A A Lone2, M H Bhat1

  • 1Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Journal of Endocrinological Investigation
|July 29, 2021
PubMed
Summary
This summary is machine-generated.

Primary hyperparathyroidism (PHPT) patients show significant cardiac abnormalities, including increased left ventricular mass and diastolic dysfunction. Echocardiography is crucial for detecting subclinical cardiac issues in PHPT management.

Keywords:
Diastolic dysfunctionLeft ventricular mass indexPrimary hyperparathyroidismValvular calcification

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Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Imaging

Background:

  • Conflicting results exist regarding cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT).
  • Symptomatic PHPT patients require comprehensive evaluation beyond traditional end organs.

Purpose of the Study:

  • To prospectively compare cardiac structure and function in symptomatic PHPT patients versus controls.
  • To identify specific echocardiographic abnormalities associated with PHPT.

Main Methods:

  • A case-control study involving 100 symptomatic PHPT patients and 113 matched controls.
  • Standardized echocardiographic evaluations performed by a single operator.

Main Results:

  • PHPT patients exhibited significantly higher left ventricular mass index (LVMI).
  • Diastolic dysfunction was evident in PHPT patients, indicated by lower E velocity and E/A ratio.
  • Increased prevalence of aortic valve, mitral annular, myocardial, and septal calcifications observed in PHPT patients.
  • Serum calcium levels negatively correlated with diastolic function (E/A ratio).

Conclusions:

  • Symptomatic PHPT is associated with significant cardiac structural and functional abnormalities.
  • Elevated LVMI, diastolic dysfunction, and various calcifications are key findings in PHPT patients.
  • Echocardiography is recommended for PHPT evaluation to detect subclinical cardiac dysfunction and optimize cardiovascular health.