Related Experiment Video
Updated: Oct 26, 2025
07:13
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.9K
Cardiac structural and functional abnormalities in primary hyperparathyroidism
S Purra1, A A Lone2, M H Bhat1
1Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
Journal of Endocrinological Investigation
|July 29, 2021
Summary
Primary hyperparathyroidism (PHPT) patients show significant cardiac abnormalities, including increased left ventricular mass and diastolic dysfunction. Echocardiography is crucial for detecting subclinical cardiac issues in PHPT management.
Area of Science:
- Cardiology
- Endocrinology
- Medical Imaging
Background:
- Conflicting results exist regarding cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT).
- Symptomatic PHPT patients require comprehensive evaluation beyond traditional end organs.
Purpose of the Study:
- To prospectively compare cardiac structure and function in symptomatic PHPT patients versus controls.
- To identify specific echocardiographic abnormalities associated with PHPT.
Main Methods:
- A case-control study involving 100 symptomatic PHPT patients and 113 matched controls.
- Standardized echocardiographic evaluations performed by a single operator.
Main Results:
- PHPT patients exhibited significantly higher left ventricular mass index (LVMI).
- Diastolic dysfunction was evident in PHPT patients, indicated by lower E velocity and E/A ratio.
- Increased prevalence of aortic valve, mitral annular, myocardial, and septal calcifications observed in PHPT patients.
- Serum calcium levels negatively correlated with diastolic function (E/A ratio).
Conclusions:
- Symptomatic PHPT is associated with significant cardiac structural and functional abnormalities.
- Elevated LVMI, diastolic dysfunction, and various calcifications are key findings in PHPT patients.
- Echocardiography is recommended for PHPT evaluation to detect subclinical cardiac dysfunction and optimize cardiovascular health.
Related Concept Videos
00:59The Parathyroid Glands
3.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
3.1K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
101
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
101
01:25Cardiomyopathy I: Introduction and Classification
140
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
140
01:28Mechanism of Cardiac Arrhythmias
1.3K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.3K
01:17Pathophysiology of Heart Failure
2.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K
01:27Heart Failure I: Introduction
166
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
166