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Updated: Oct 26, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Deep Herpes.

Melissa Krystel-Whittemore¹, May P Chan², Sara C Shalin^3,4

¹Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston.

The American Journal of Surgical Pathology

|July 29, 2021

Summary

This summary is machine-generated.

This study reveals that herpes viruses can infect deep skin stromal cells, a previously unreported condition called cutaneous stromal herpes. This deep infection may mimic other skin conditions, especially in immunocompromised patients.

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Area of Science:

Dermatology
Virology
Pathology

Background:

Herpes viruses typically infect epithelial cells, causing vesicular lesions.
Ocular stromal infections by herpes viruses are known, but cutaneous stromal herpes is undocumented.
Deep herpes infections may evade typical clinical and microscopic detection.

Purpose of the Study:

To identify and characterize cutaneous stromal herpes infections.
To raise awareness of this deep herpes manifestation in clinical practice.

Main Methods:

Retrospective search for skin biopsies with suspected herpes stromal disease.
Analysis of clinical, histopathological (H&E, IHC), and molecular (PCR) data.
Identification of herpes simplex virus 1/2 and varicella-zoster virus in stromal tissues.

Main Results:

12 specimens from 10 patients with cutaneous stromal herpes (HSV-1/2 or VZV) were identified.
Common sites included the buttocks/perianal region; ulceration was frequent.
Most cases (80%) occurred in immunosuppressed individuals and often mimicked pyoderma gangrenosum.

Conclusions:

This is the first report of herpes viruses infecting deep dermal stromal cells (cutaneous stromal herpes).
Awareness is crucial for diagnosing atypical lesions, especially in immunocompromised patients.
Accurate diagnosis is essential for appropriate therapeutic intervention.