Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 26, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

13.0K

Comprehensive Development in Organ-On-A-Chip Technology.

X Joseph1, V Akhil1, A Arathi1

  • 1Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (Govt. of India), Poojapura, Trivandrum 695012, Kerala, India.

Journal of Pharmaceutical Sciences
|July 29, 2021
PubMed
Summary

Organ-on-a-chip technology revolutionizes drug development by offering advanced in vitro models for absorption, distribution, metabolism, excretion (ADME), and toxicity assessments, improving preclinical safety evaluations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose.

Canadian journal of physiology and pharmacology·2026
Same author

Mitochondrial disease management through phytochemical interventions.

Molecular and cellular biochemistry·2025
Same author

Unveiling the multifaceted bioactivity of copper(II)-Schiff base complexes: a comprehensive study of antioxidant, anti-bacterial, anti-inflammatory, enzyme inhibition and cytotoxic potentials with DFT insights.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Bio distribution and acute toxicity profiling of Pluronic F127 coated Titanium dioxide nanotubes in adult Wistar rats.

Colloids and surfaces. B, Biointerfaces·2024
Same author

Environmental impact of microplastics and potential health hazards.

Critical reviews in biotechnology·2024
Same author

Chitra Disinfection Gateway for the Management of COVID 19 in Public Entry Places.

Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology·2024

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Toxicology

Background:

  • Conventional in vitro tests for drug evaluation are being replaced by advanced organ-on-a-chip (OOC) technology.
  • There is a growing need for accurate predictive models to assess drug toxicity and mitigate risks in drug development.
  • OOC technology offers a contemporary in vitro model for pharmacokinetic and pharmacodynamic (PK-PD) studies.

Purpose of the Study:

  • To review the development and applications of organ-on-a-chip technology in drug development.
  • To highlight the advantages of OOC models over traditional 2D culture systems.
  • To discuss the use of OOCs in toxicity evaluation and efficacy studies.

Main Methods:

  • Review of organ-on-a-chip technology advancements.
Keywords:
Disease modellingMicrofluidicsOrgan-on-a-chipPrecision medicineToxicity

More Related Videos

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

14.1K
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.0K

Related Experiment Videos

Last Updated: Oct 26, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

13.0K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

14.1K
Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

27.0K
  • Analysis of various OOC models and their configurations.
  • Examination of OOC applications in drug absorption, distribution, metabolism, excretion (ADME), and toxicity assessments.

    • Main Results:

    • OOC technology provides a platform mimicking human physiological functions with precise flow control and rapid sample processing.
    • Multi-organ-on-a-chip systems offer insights into time- and dose-dependent drug effects.
    • OOCs represent a significant advancement over conventional 2D cell cultures for preclinical drug testing.

    Conclusions:

    • Organ-on-a-chip technology is a transformative tool for preclinical drug development, enhancing ADME and toxicity evaluations.
    • The integration of OOCs in drug discovery pipelines promises more accurate predictions of drug safety and efficacy.
    • Continued development of OOCs is crucial for advancing personalized medicine and reducing reliance on animal testing.