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Related Experiment Video

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A Protocol for Transcranial Photobiomodulation Therapy in Mice
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Photobiomodulation for the aging brain.

Fabrízio Dos Santos Cardoso1, F Gonzalez-Lima2, Sérgio Gomes da Silva3

  • 1Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil; Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.

Ageing Research Reviews
|July 29, 2021
PubMed
Summary
This summary is machine-generated.

Photobiomodulation (PBM) shows promise for improving brain function in aging individuals. This non-pharmacological approach may enhance cognitive abilities and mood in older adults, warranting further research.

Keywords:
Photobiomodulationagingbraininflammationlearninglow level laser therapymemorymetabolism

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomedical Engineering

Background:

  • Global population is aging, leading to increased prevalence of age-related cognitive decline and neurological disorders like Alzheimer's and Parkinson's.
  • Non-pharmacological interventions are sought for neurocognitive impairment prevention and treatment.
  • Photobiomodulation (PBM) is emerging as a promising intervention for age-related brain issues.

Purpose of the Study:

  • To review the primary brain effects of PBM in aging.
  • To discuss PBM's mechanisms of action relevant to the aging brain.
  • To advocate for more controlled studies on PBM in older populations.

Main Methods:

  • Review of existing animal and human studies on PBM and brain function.
  • Analysis of PBM's effects on metabolic and hemodynamic brain parameters.
  • Examination of PBM's impact on electrophysiological activity and cognitive functions.

Main Results:

  • PBM demonstrates neuroprotective and neuromodulatory effects in animal models.
  • Studies show PBM improves mitochondrial and vascular functions in the brain.
  • Human studies indicate PBM enhances attention, learning, memory, and mood in older adults.

Conclusions:

  • PBM offers potential benefits for brain health during aging.
  • Further controlled clinical trials are necessary to validate PBM's efficacy in older populations.
  • PBM represents a viable non-pharmacological strategy for mitigating age-related cognitive decline.